Adaptive CRT Effect on Electrical Dyssynchrony (aCRT-ELSYNC)
The goals of this randomized controlled trial are: (1) to determine if aCRT is superior to standard CRT, as evidenced by a superior degree of reduction of electrical dyssynchrony 6-month post-CRT, and (2) to determine if a surface ECG metric sum absolute QRST integral (SAI QRST) is a superior estimate of electrical dyssynchrony, as compared to QRS duration.
Hypertrophic Cardiomyopathy Pilot Study
Pilot observational case-control study of electrical heterogeneity in patients with HCM and high arrhythmic-risk.
The objective of this case-control study is an investigation of mechanisms of ventricular arrhythmias in hypertrophic cardiomyopathy.
Assessment of S-ICD Eligibility With 12-Lead ECG (EL-SID)
The primary objective of this study is to develop an approach to determine eligibility for subcutaneous ICD by analyzing routine clinical 12-lead electrocardiogram.
Global Electrical Heterogeneity and Clinical Outcomes
This retrospective multicenter cohort will validate an independent association of electrocardiographic (ECG) global electrical heterogeneity (GEH) measures with sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD, and will validate and re-calibrate GEH ECG risk score for prediction of sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD.
Cardiovascular Risk Stratification in Covid-19 (CaVaR-Co19)
This retrospective double-cohort study seeks to describe the cardiovascular manifestations and electrophysiological (EP) substrate in COVID-19 infection and their association with clinical outcomes and develop a method of cardiovascular risk stratification in COVID-19.
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