Editorial written by Tereshchenkolab members is published today by Circulation: Arrhythmia and Electrophysiology. Dr. Perez-Alday and Dr. Tereshchenko discussed results of a modeling study by Huntjens et al. Computer modeling demonstrated that increasing degrees of interventricular dyssynchrony (defined as the difference between mean RV free wall activation time and mean LV free wall activation time) resulted in the largest improvements in dP/dtmax and therefore would be expected to result in improved rates of clinical CRT response. However, intraventricular dyssynchrony (defined as LV total activation time or the difference in activation time between the earliest and latest sites within the LV free wall) had minimal effect on LV dP/dtmax.
Our manuscript is published today in JAHA. Uncovering mechanisms behind Global Electrical Heterogeneity: mechanisms of ventricular conduction abnormalities, left-to-right asymmetry, and more: 10 independent genetic loci identified. Specific “electrical signatures”—a specific pattern of associations with the GEH ECG phenotype is suggesting variable underlying biological and electrophysiological phenomena underlying each locus, which reflects multifactorial nature of GEH.