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Global Electrocardiographic Measures and Cardiac Structure and Function: The Atherosclerosis Risk in

Our manuscript is published by the Circulation: Arrhythmia and Electrophysiology !

In a large prospective cohort study, we demonstrated that ECG global electrical heterogeneity (GEH) reflects subclinical abnormalities in cardiac structure and function and represents one mechanism by which abnormal electrophysiological substrate may lead to an increased risk of left ventricular dysfunction and sudden cardiac death.

Healthy aging in spite of a lifelong cardiovascular disease risk factor exposure is characterized by longitudinal changes in spatial ventricular gradient azimuth, manifest as a rotation of the spatial ventricular gradient vector.

Slow worsening of GEH over time is associated with subsequent left ventricular dysfunction, whereas rapid worsening of GEH is associated with an increased risk of sudden cardiac death.

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