Plasticizer Interaction With the Heart: Chemicals Used in Plastic Medical Devices Can Interfere With
Our collaborative work with Dr.Nikki Posnack is published in Circulation EP!
- Acute phthalate exposure slowed atrioventricular conduction and increased atrioventricular node effective refractory period in an intact, whole heart model. - Phthalate exposure prolonged action potential duration time, enhanced action potential triangulation, and increased the ventricular effective refractory period. - Phthalate exposure slowed epicardial conduction velocity, which may be partly explained by inhibition of Nav1.5
This important work shade the light on mechanisms of sudden cardiac death in end-stage kidney disease patients undergoing dialysis.