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Plasticizer Interaction With the Heart: Chemicals Used in Plastic Medical Devices Can Interfere With


Our collaborative work with Dr.Nikki Posnack is published in Circulation EP!

Main findings:

- Acute phthalate exposure slowed atrioventricular conduction and increased atrioventricular node effective refractory period in an intact, whole heart model. - Phthalate exposure prolonged action potential duration time, enhanced action potential triangulation, and increased the ventricular effective refractory period. - Phthalate exposure slowed epicardial conduction velocity, which may be partly explained by inhibition of Nav1.5

This important work shade the light on mechanisms of sudden cardiac death in end-stage kidney disease patients undergoing dialysis.


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