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Plasticizer Interaction With the Heart: Chemicals Used in Plastic Medical Devices Can Interfere With Cardiac Electrophysiology

June 28, 2019

Our collaborative work with Dr.Nikki Posnack  is published in Circulation EP!

 

Main findings:

- Acute phthalate exposure slowed atrioventricular conduction and increased atrioventricular node effective refractory period in an intact, whole heart
model.
- Phthalate exposure prolonged action potential duration time, enhanced action potential triangulation, and increased the ventricular effective refractory period.
- Phthalate exposure slowed epicardial conduction velocity, which may be partly explained by inhibition of Nav1.5

This important work shade the light on mechanisms of sudden cardiac death in end-stage kidney disease patients  undergoing dialysis. 

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Larisa Tereshchenko and her team received prestigious NIH R56 award to continue study of sudden cardiac death. We will continue study of global electr...

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