Short-term and long-term predictive accuracy of ECG biomarkers of SCD differed, reflecting differences in transient vs. persistent SCD substrates. The dynamic predictive accuracy of ECG biomarkers should be considered for competing SCD risk scores. The distinction between markers predicting short-term and long-term events may represent the difference between markers heralding SCD (triggers or transient substrates) versus markers identifying persistent substrate.
Our collaborative paper with Dr. Jonathan Waks' team is now in press in Heart Rhythm! AADs change GEH measurements. These changes, which differ by gender, are likely driven by alterations in ion-channel function and dispersion of depolarization or repolarization. GEH measurement may allow early assessment of favorable or adverse AAD effects.
- Nonsustained ventricular tachycardia is more frequent during hemodialysis or within 6 hours post-hemodialysis.
- In incident hemodialysis patients, heart rate sharply increases before nonsustained ventricular tachycardia events, suggesting a triggered ventricular tachycardia mechanism.
- Every‐other‐day hemodialysis preserves physiological circadian rhythm in heart rate and heart rate variability, whereas the extension of the interdialytic period for the second day abolishes circadian rhythm and shows a steady deterioration in autonomic disbalance.
- The harmful effect of the 2‐day interval without hemodialysis suggests that more frequent dialysis should be considered the preferred prescribed treatment schedule.
Improvement of patient adherence—avoiding missing hemodialysis sessions—can improve patient outcomes.
- Diagnosis of autonomic imbalance in end‐stage...
Two abstracts of the Tereshchenko lab members were accepted for the presentations at AHA SS in Philadelphia!!! Congratulations to Kazi and Ashley! We are looking forward to reporting results of our studies at the major cardiovascular meeting!
- Acute phthalate exposure slowed atrioventricular conduction and increased atrioventricular node effective refractory period in an intact, whole heart
- Phthalate exposure prolonged action potential duration time, enhanced action potential triangulation, and increased the ventricular effective refractory period.
- Phthalate exposure slowed epicardial conduction velocity, which may be partly explained by inhibition of Nav1.5
This important work shade the light on mechanisms of sudden cardiac death in end-stage kidney disease patients undergoing dialysis.