Complexity of Coronary Heart Disease Manifestation on Electrocardiogram: Atrial Infarction

Larisa Tereshchenko, MD, PhD

JACC: Case Reports, Available online 6 May 2025, 103392

https://www.sciencedirect.com/science/article/pii/S2666084925001640 

May 2025. Dr. Hassaan Bukhari was awarded the Cleveland Clinic and the Novo Nordisk Foundation AI Biomedical Frontiers Fellowship for the project "AI-Driven Electrocardiography for the Early Detection and Management of Occlusion Myocardial Infarction in the Danish Population".   

Congratulations, Hassaan! 

May 2025. Dr. Larisa Tereshchenko was selected as a 2025 Fellow of the Society for Clinical Trials in recognition of her contribution to advancing human health. This honor supports the Society's mission to promote the development of optimal clinical trials methods and practices, as well as to promote education for clinical trial professionals.  

April 2025. Dr. Rajkumar Dhar was awarded the 2nd prize for Outstanding Poster Presentation at the 2025 Joint Biostatistics Symposium of Ohio (CCF/CWRU/OSU) . 

Congratulations, Rajkumar!!!

Hassaan Bukhari and Shivangi Kewalramani also presented poster presentations at the Symposium.

March 2025. Dr. Hassaan Bukhari and Dr. Rajkumar Dhar presented posters at the Research Discovery Day,  Clinical and Translational Science Collaborative (CTSC) of Northern Ohio at Case Western Reserve University.  Both presentations were well-received and well-attended.

A call for transparency, improved reporting, and interpretation of trials using surrogate end points in cardiac electrophysiology.

Tereshchenko LG, Manyara AM, Ciani O, Sodeke SO, Bradford CN, Santangeli P, Kapadia SR, Wazni O, Narayan SM, Chugh SS, Bilchick K, Huizar JF, Vaseghi M, Chung MK, Ellenbogen KA, Taylor RS. Heart Rhythm. 2025 Feb 26:S1547-5271(25)00209-7. doi: 10.1016/j.hrthm.2025.02.038. 

October 2024. Dr. Hassaan Bukhari is F. Merlin Bumpus Junior Investigator Award Basic Science Finalist and F. Merlin Bumpus Junior Investigator Award Clinical Science Finalist !!! 

Congratulations, Hassaan!!!

Prevention of Heart Failure in Hypertension-the Role of Coronary Heart Disease Events Treated With Versus Without Revascularization: The ALLHAT Study. 

Chen V, Davis BR, Kapadia SR, Kattan MW, Tereshchenko LG. Am J Cardiol. 2024 Nov 15;231:1-10. doi: 10.1016/j.amjcard.2024.08.033. Epub 2024 Sep 5. PubMed PMID: 39243877.

Sex Differences in Global Electrical Heterogeneity: The Hispanic Community Health Study/Study of Latinos.

Larisa G. Tereshchenko, Kazi T. Haq, Stacey J. Howell, Evan C. Mitchell, Jessica Hyde, Jesús Martínez, Cassandra A. Ahmed, Genesis Briceno, Hetal Patel, Jose Pena, Akram Khan, Elsayed Z. Soliman, João A.C. Lima, Samir R. Kapadia, Anita D. Misra-Hebert, Mayank M. Kansal, Martha L. Daviglus, Robert Kaplan. Heart Rhythm O2, 2024, ISSN 2666-5018. https://doi.org/10.1016/j.hroo.2024.11.019. (https://www.sciencedirect.com/science/article/pii/S2666501824003891) 

Electrical Heterogeneity in Hispanic Background Subpopulations. 

Tereshchenko LG, Haq KT, Howell SJ, Mitchell EC, Hyde J, Martínez J, Ahmed CA, Briceno G, Patel H, Pena J, Khan A, Soliman EZ, Lima JAC, Kapadia SR, Misra-Hebert AD, Kattan MW, Kansal MM, Daviglus ML, Kaplan R. JACC: Advances.0(0). null2024, 0 (0) https://doi.org/10.1016/j.jacadv.2024.101225.  

 Latent profiles of global electrical heterogeneity: the Hispanic Community Health Study/Study of Latinos. 

Larisa G Tereshchenko, Kazi T Haq, Stacey J Howell , Evan C Mitchell, Jesús Martínez, Jessica Hyde, Genesis Briceno, Jose Pena, Edvinas Pocius, Akram Khan, Elsayed Z Soliman, João A C Lima, Samir R Kapadia, Anita D Misra-Hebert, Michael W Kattan, Mayank M Kansal, Martha L Daviglus, Robert Kaplan. Eur Heart J Digit Health. 2024 Jul 8;5(5):611-621. doi: 10.1093/ehjdh/ztae048. eCollection 2024 Sep. PMID: 39318685 PMCID: PMC11417492 DOI: 10.1093/ehjdh/ztae048

Competing Risks for Monomorphic versus Non-Monomorphic Ventricular Arrhythmias in Primary Prevention Implantable Cardioverter Defibrillator Recipients: Global Electrical Heterogeneity and Clinical Outcomes (GEHCO) Study.

Tereshchenko LG, Waks JW, Tompkins C, Rogers AJ, Ehdaie A, Henrikson CA, Dalouk K, Raitt M, Kewalramani S, Kattan MW, Santangeli P, Wilkoff BW, Kapadia SR, Narayan SM, Chugh SS.

Europace. 2024 May 4:euae127. https://doi.org/10.1093/europace/euae127 .  PMID: 38703375

VT/VF risk calculator: https://riskcalc.org/VTVF/ 

Pulseless Electric Activity or Electromechanical Dissociation. 

Editorial in Circulation: Arrhythmia and Electrophysiology. 

An electrophysiological substrate of COVID-19

Our manuscript has been published in the Journal of Electrocardiology! 

We conducted a double-cohort study of patients with the positive versus negative  SARS-CoV-2 PCR test. We conducted a longitudinal analysis and compared 3 ECGs: (1) baseline (before COVID-19), (2) at the time of infection, and (3) after infection. Baseline ECGs were recorded, on average, 3.0±0.3 years before the index COVID-19 ECG (recorded within 30 days of the PCR SARS-CoV-2 test). PCR tests and index ECG recordings were performed on the same day in most patients. Subsequent follow-up ECGs were recorded on average 1.3 ± 0.7 months after the index COVID-19 ECG. 

To compare changes in ECG metrics before-during-after COVID-19 in two COVID-19 exposure cohorts, we constructed linear random effect panel data models, adjusted for demographic (age, sex, and race-ethnicity categories), socioeconomic characteristics (insurance status), the reason for testing (presence or absence of COVID-19 symptoms), body mass index, medical history of cardiovascular, cerebrovascular, respiratory, kidney, liver, blood, systemic, endocrine disease, diabetes mellitus, substance addiction including smoking, conditions with immunocompromised and thromboembolic risk, use of prescription medications (including QT-prolonging drugs, Renin-Angiotensin-Aldosterone System-blocking drugs, atrioventricular-nodal agents, antiplatelet or anticoagulant, and immunosuppressants), and the longitudinal changes in RR’ intervals, ventricular conduction type (left or right bundle branch block, or intraventricular conduction delay) and the type of median beat (Normal Sinus, Atrial Fibrillation, Ventricular Paced). 

The major finding of this retrospective, longitudinal, double-cohort study was the observation of post-acute cardiovascular sequelae of either symptomatic or asymptomatic SARS-CoV-2 infection, manifested by the development of EP substrate on average 40 days after index COVID-19 episode. Notably, after comprehensive adjustment, cardiovascular sequelae of SARS-CoV-2 infection manifested by QTc prolongation and rotation of the Spatial Ventricular Gradient (SVG) vector upward.

 2021 in review: Media   Appearances & Coverage

https://www.science.org/content/article/covid-19-takes-serious-toll-heart-health-full-year-after-recovery

https://www.washingtonpost.com/nation/2022/02/10/covid-omicron-variant-live-updates/

https://www.npr.org/sections/health-shots/2022/03/05/1084413347/for-some-patients-cardiovascular-problems-persist-long-after-covid.

https://www.scientificamerican.com/article/even-mild-covid-can-increase-the-risk-of-heart-problems/?amp;text=Even.