Competing Risks for Monomorphic versus Non-Monomorphic Ventricular Arrhythmias in Primary Prevention Implantable Cardioverter Defibrillator Recipients: Global Electrical Heterogeneity and Clinical Outcomes (GEHCO) Study.

Tereshchenko LG, Waks JW, Tompkins C, Rogers AJ, Ehdaie A, Henrikson CA, Dalouk K, Raitt M, Kewalramani S, Kattan MW, Santangeli P, Wilkoff BW, Kapadia SR, Narayan SM, Chugh SS.

Europace. 2024 May 4:euae127. .  PMID: 38703375

VT/VF risk calculator: 

Larisa Tereshchenko is recognized as a Remarkable Reviewer by the Heart Rhythm Journal Year 2023 

Pulseless Electric Activity or Electromechanical Dissociation. 

Editorial in Circulation: Arrhythmia and Electrophysiology. 

Society for Clinical Trials Award to Larisa Tereshchenko

Larisa Tereshchenko received Award for Leadership and Outstanding Service as Education Committee Chair 2022-2023,  Society for Clinical Trials.

An electrophysiological substrate of COVID-19

Our manuscript has been published in the Journal of Electrocardiology

We conducted a double-cohort study of patients with the positive versus negative  SARS-CoV-2 PCR test. We conducted a longitudinal analysis and compared 3 ECGs: (1) baseline (before COVID-19), (2) at the time of infection, and (3) after infection. Baseline ECGs were recorded, on average, 3.0±0.3 years before the index COVID-19 ECG (recorded within 30 days of the PCR SARS-CoV-2 test). PCR tests and index ECG recordings were performed on the same day in most patients. Subsequent follow-up ECGs were recorded on average 1.3 ± 0.7 months after the index COVID-19 ECG. 

To compare changes in ECG metrics before-during-after COVID-19 in two COVID-19 exposure cohorts, we constructed linear random effect panel data models, adjusted for demographic (age, sex, and race-ethnicity categories), socioeconomic characteristics (insurance status), the reason for testing (presence or absence of COVID-19 symptoms), body mass index, medical history of cardiovascular, cerebrovascular, respiratory, kidney, liver, blood, systemic, endocrine disease, diabetes mellitus, substance addiction including smoking, conditions with immunocompromised and thromboembolic risk, use of prescription medications (including QT-prolonging drugs, Renin-Angiotensin-Aldosterone System-blocking drugs, atrioventricular-nodal agents, antiplatelet or anticoagulant, and immunosuppressants), and the longitudinal changes in RR’ intervals, ventricular conduction type (left or right bundle branch block, or intraventricular conduction delay) and the type of median beat (Normal Sinus, Atrial Fibrillation, Ventricular Paced). 

The major finding of this retrospective, longitudinal, double-cohort study was the observation of post-acute cardiovascular sequelae of either symptomatic or asymptomatic SARS-CoV-2 infection, manifested by the development of EP substrate on average 40 days after index COVID-19 episode. Notably, after comprehensive adjustment, cardiovascular sequelae of SARS-CoV-2 infection manifested by QTc prolongation and rotation of the Spatial Ventricular Gradient (SVG) vector upward.

Larisa Tereshchenko is recognized as Remarkable Reviewer by the Heart Rhythm Journal Year 2022