Major Projects & Funding
We are immensely grateful for the past and current support of our research projects by the NIH, American Heart Association, Cleveland Clinic, OHSU, JHU, and philanthropic support. We are committed to our mission, asking important clinical questions focused on improving human health. Our research is solely funded through grants.
Current Research Projects
American Heart Association Transformational Project Award: Electrical dyssynchrony and heart failure
We aim to refine the definition of electrical dyssynchrony.
American Heart Association Innovative Project Award: Atrial Fibrillation Mapping Using Phase-Aligned Spectral Filtering for Decomposing Spatiotemporal Dynamics
We aim to develop a novel approach to Atrial Fibrillation mapping.
Completed Research Projects
NHLBI R01-R56. Novel ECG Measures and Risk of Sudden Cardiac Death
This ancillary ARIC and CHS study has 3 goals: (1) discovery of novel SCD mechanisms in the general population and development of novel mechanistic ECG risk markers of SCD; (2) development and validation of the novel resting 12-lead ECG risk score of SCD risk in the analysis of community-dwelling cohorts of adults, and (3) discovery of genetic loci associated with the novel mechanistic ECG phenotypes
American Heart Association Grant-In-Aid. Global Electrical Heterogeneity and Clinical Outcomes.
This retrospective multicenter cohort validated an independent association of electrocardiographic (ECG) global electrical heterogeneity (GEH) measures with sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD, validated and re-calibrated GEH ECG risk score for prediction of sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD.
American Heart Association Clinical Research Program. Ventricular tachyarrhythmias across the continuum of left ventricular dysfunction.
This retrospective study developed the concept of electrocardiographic (ECG) global electrical heterogeneity (GEH). The study conducted analyses of two retrospective cohorts: ICD-EGMs and PROSE-ICD study ( PRospective Observational Study of the ICD in Sudden Cardiac Death).